HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-[(3-formyl-thien-2-yl)sulfonyl]glycine ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-[[3-(1,3-dioxolan-2-yl)-2-thienyl]sulfonyl]glycine ethyl ester | HCID 21480494 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | N-[(3-formyl-thien-2-yl)sulfonyl]glycine ethyl ester | HCID 21480488 | 82% |
Reaction Steps
To a solution of the product from Step A (31.0 g 97.0 mmol) in THF (100 mL) was added 3N HCl and the mixture stirred for 6 h at room temperature. Brine (100 mL) was added and the mixture extracted with ethyl acetate (3×100 mL). The combined extracts were washed with brine (20.0 mL), dried (MgSO4) and evaporated to yield a white solid (22.0 g, 82%): mp 74°-76° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05681834 |
| Source dataset | uspto-grants-1997_10 |
| ORD ID | ord-318a40ba4ce4467d9212f159c104f3ee |
| Source note | uspto-grants-1997_10 |