Trifluoroacetic acid → HCID 67709598, compound

HRID 1490085Notes

Reaction equation

C(OC([NH:8][CH2:9][CH2:10][CH2:11][N:12]([CH2:27][C:28]([OH:30])=[O:29])[C:13]([NH:15][CH:16]([C:23]([O:25][CH3:26])=[O:24])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:14])=O)(C)(C)C.[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34]>>[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34].[NH2:8][CH2:9][CH2:10][CH2:11][N:12]([CH2:27][C:28]([OH:30])=[O:29])[C:13]([NH:15][CH:16]([C:23]([O:25][CH3:26])=[O:24])[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)=[O:14]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 15295998HCID 15295998, compound

Product 1

HCID 67709598HCID 67709598, compound

Procedure

2.3 g (5.4 mmol) of (1-(3-tert-butoxycarbonylaminopropyl)-3-(methoxycarbonylphenylmethyl)ureido)acetic acid are stirred at room temperature for 2 h together with 20 ml of 90% strength aqueous trifluoroacetic acid. After concentrating, the mixture is freeze dried.

Workup

concentrationAfter concentrating
customdried

Sources & evidence

ORD record: ord-d8032abcd2d64b6aa78925b847e85c29
Source dataset: uspto-grants-1997_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05681838

Reaction notes

Loading…