Hydrochloric Acid → HCID 67709577, compound

HRID 1490088Notes

Reaction equation

HRID 1490088 reaction equation
[NH2:1][N:2]=[CH:3][C:4]1[CH:41]=[CH:40][C:7]([CH2:8][CH:9]2[C:13](=[O:14])[N:12]([CH2:15][CH2:16][CH:17]([NH:21][C:22]([O:24][CH2:25][CH:26]3[C:38]4[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=4[C:32]4[C:27]3=[CH:28][CH:29]=[CH:30][CH:31]=4)=[O:23])[C:18]([OH:20])=[O:19])[C:11](=[O:39])[NH:10]2)=[CH:6][CH:5]=1.[ClH:42]>C(O)(=O)C>[ClH:42].[NH2:1][N:2]=[CH:3][C:4]1[CH:5]=[CH:6][C:7]([CH2:8][CH:9]2[C:13](=[O:14])[N:12]([CH2:15][CH2:16][CH:17]([NH:21][C:22]([O:24][CH2:25][CH:26]3[C:27]4[CH:28]=[CH:29][CH:30]=[CH:31][C:32]=4[C:33]4[C:38]3=[CH:37][CH:36]=[CH:35][CH:34]=4)=[O:23])[C:18]([OH:20])=[O:19])[C:11](=[O:39])[NH:10]2)=[CH:40][CH:41]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67709564HCID 67709564, compound

Product 1

HCID 67709577HCID 67709577, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1.2 g (1.88 mmol) of (2-(4-(4-(aminoiminomethyl)benzyl)-2,5-dioxoimidazolidin-1-yl)ethyl)-(9-fluorenylmethoxycarbonyl)aminoacetic acid are heated at 90° C. for 20 minutes together with 24 ml of 10% strength hydrochloric acid and 24 ml of acetic acid. Following concentration, chromatography takes place, for purification, on Sephadex LH20 using methanol.

Workup

  1. concentrationconcentration, chromatography
  2. customfor purification

Sources & evidence

ORD record
ord-f04422449bdc4aeba8919e77185b641a
Source dataset
uspto-grants-1997_10
Patent number
US05681838

Reaction notes

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