Thionyl Chloride → HCID 86751451, compound

HRID 1490093Notes

Reaction equation

HRID 1490093 reaction equation
S(Cl)([Cl:3])=O.C(OC([NH:12][CH2:13][CH2:14][N:15]([CH2:30][C:31]([OH:33])=O)[C:16]([NH:18][CH:19]([C:26]([O:28][CH3:29])=[O:27])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:17])=O)(C)(C)C>CO>[ClH:3].[NH2:12][CH2:13][CH2:14][N:15]1[CH2:30][C:31](=[O:33])[N:18]([CH:19]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:26]([O:28][CH3:29])=[O:27])[C:16]1=[O:17]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 21480546HCID 21480546, compound

Product 1

HCID 86751451HCID 86751451, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.9 ml (12 mmol) of thionyl chloride are added dropwise, at 0° C., to 4.1 g (10 mmol) of (1-(2-tertbutoxycarbonylaminoethyl)-3-(methoxycarbonylphenylmethyl)ureido)acetic acid in 50 ml of methanol. The mixture is allowed to warm to room temperature and then stirred further overnight, followed by filtering off with suction and drying.

Workup

  1. filtrationby filtering off with suction
  2. customdrying

Sources & evidence

ORD record
ord-22a52a54efb7443094e37ede896cc6cd
Source dataset
uspto-grants-1997_10
Patent number
US05681838

Reaction notes

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