Tetrahydrofuran → HCID 70078117, compound

HRID 1490114Notes

Reaction equation

HRID 1490114 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][N:10]([C:13]3[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][C:21]([O:23]CC)=[O:22])=[CH:15][CH:14]=3)[C:9]2=[O:26])=[CH:4][CH:3]=1.O1CCCC1.[OH-].[Na+]>O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][N:10]([C:13]3[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:15][CH:14]=3)[C:9]2=[O:26])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 70075765HCID 70075765, compound

Product 1

HCID 70078117HCID 70078117, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

12.7 g of 3-(4-bromophenyl)-1-[4-[2-(ethoxycarbonyl)-ethyl]-phenyl]-imidazolidin-2-one, 300 ml of tetrahydrofuran, 100 ml of water and 23.6 ml of 4N sodium hydroxide solution are stirred overnight at ambient temperature. The precipitate is suction filtered, suspended in 1 liter of water, acidified with concentrated hydrochloric acid and stirred for 2 hours. It is then suction filtered, washed with water and dried at 60° C.

Workup

  1. filtrationfiltered
  2. filtrationsuction filtered
  3. washwashed with water
  4. customdried at 60° C.

Sources & evidence

ORD record
ord-ef9f38b63278443bbea027ef5a6a2e91
Source dataset
uspto-grants-1997_10
Patent number
US05681841

Reaction notes

Loading…