HCID 178504080, compound → HCID 178504079, compound

HRID 1490129Notes

Reaction equation

HRID 1490129 reaction equation
[CH3:1][S:2]([CH3:5])(=[O:4])=[O:3].[CH2:6]([S:13]([NH:16][C@H:17]([C:25]([OH:27])=[O:26])[CH2:18][S:19][C:20]1[NH:24][N:23]=[N:22][N:21]=1)(=[O:15])=[O:14])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C([O:35][C:36](=[O:42])[C@@H:37]1[CH2:41][CH2:40][CH2:39][NH:38]1)C1C=CC=CC=1>C1COCC1.[Pd]>[CH3:1][S:2]([CH3:5])(=[O:4])=[O:3].[CH2:6]([S:13]([NH:16][C@H:17]([C:25]([OH:27])=[O:26])[CH2:18][S:19][C:20]1[NH:24][N:23]=[N:22][N:21]=1)(=[O:14])=[O:15])[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1.[NH:38]1[CH2:39][CH2:40][CH2:41][C@H:37]1[C:36]([OH:42])=[O:35]

Participants

4

Reactant 1

HCID 178504080HCID 178504080, compound

Product 1

HCID 178504079HCID 178504079, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

The compound of Example 75 (2.77 g, 4.81 mmole) is dissolved in THF (50 mL), 0.5 g of 10% palladium on carbon is added and the mixture is stirred under hydrogen gas at atmospheric pressure for 18 hours.

Sources & evidence

ORD record
ord-304bab208a514b1b84d09f6136b185d4
Source dataset
uspto-grants-1997_10
Patent number
US05681844

Reaction notes

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