Acetic Acid → HCID 21480568, compound

HRID 1490155Notes

Reaction equation

HRID 1490155 reaction equation
[C:1]([CH:3]([CH3:21])[CH2:4][CH:5]1[CH2:10][CH:9]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=2)[CH2:8][CH2:7][C:6]1=O)#[N:2].Br.C(O)(=[O:25])C>>[CH3:19][O:18][C:15]1[CH:16]=[CH:17][C:12]([CH2:11][CH:9]2[CH2:8][CH2:7][C:6]3[NH:2][C:1](=[O:25])[CH:3]([CH3:21])[CH2:4][C:5]=3[CH2:10]2)=[CH:13][CH:14]=1

Participants

4

Reactant 3

HCID 176Acetic Acid2×HCID 260Hydrogen BromideHCID 18919716HCID 18919716, compound

Product 1

HCID 21480568HCID 21480568, compound

Procedure

2-(2-Cyanopropyl)-4-(4-methoxybenzyl)cyclohexanone (1.5 g) was added to glacial acetic acid (20 ml) containing 45% w/v hydrogen bromide in acetic acid (5 ml) and the mixture was left to stir for 21/2 hours. The solvent was removed under reduced pressure, the residue was suspended in water and filtered to give the title compound on recrystallisation (0.5 g) mp 182°-184° C.

Workup

  1. additioncontaining 45%
  2. waitthe mixture was left
  3. customThe solvent was removed under reduced pressure
  4. filtrationfiltered

Sources & evidence

ORD record
ord-c03cd5916f0244b4847a639d785f4209
Source dataset
uspto-grants-1997_10
Patent number
US05681839

Reaction notes

Loading…