Tetrabutylammonium Fluoride → HCID 54295887, compound

HRID 1490175Notes

Reaction equation

HRID 1490175 reaction equation
[NH2:1][C@@:2]1([N:24]2[CH2:32][C:30](CO[Si](C(C)(C)C)(C)C)([CH3:31])[C:28](=[O:29])[NH:27][C:25]2=[O:26])[O:16][C@H:6]([CH:7]([Si](C(C)(C)C)(C)C)[OH:8])[C@@:4]([Si](C(C)(C)C)(C)C)([OH:5])[CH2:3]1.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>C1COCC1>[NH2:1][C@@:2]1([N:24]2[CH:32]=[C:30]([CH3:31])[C:28](=[O:29])[NH:27][C:25]2=[O:26])[O:16][C@H:6]([CH2:7][OH:8])[C@@H:4]([OH:5])[CH2:3]1

Participants

4

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 131720263HCID 131720263, compound

Product 1

HCID 54295887HCID 54295887, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A suspension of 1'-amino-3',5'-bis(t-butyldimethylsilyl)-5-t-butyldimethylsiloxymethyl thymidine and tetrabutylammonium fluoride in THF stands at room temperature for one hour. The solvent is evaporated and the residue chromatographically separated on silica.

Workup

  1. customThe solvent is evaporated
  2. customthe residue chromatographically separated on silica

Sources & evidence

ORD record
ord-d613241ad10e4bc88d9b91cb0200bc62
Source dataset
uspto-grants-1997_10
Patent number
US05681940

Reaction notes

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