Phosphorus oxide (P4O10) → HCID 18977309, compound

HRID 1490262Notes

Reaction equation

HRID 1490262 reaction equation
O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O.[F:15][C:16]([F:34])([F:33])[O:17][C:18]1[CH:32]=[CH:31][C:21]([O:22]/[C:23](=[CH:27]\[C:28]([OH:30])=O)/[C:24]([OH:26])=[O:25])=[CH:20][CH:19]=1>CS(O)(=O)=O>[F:33][C:16]([F:15])([F:34])[O:17][C:18]1[CH:19]=[C:20]2[C:21](=[CH:31][CH:32]=1)[O:22][C:23]([C:24]([OH:26])=[O:25])=[CH:27][C:28]2=[O:30]

Participants

4

Reactant 2

HCID 14812Phosphorus oxide (P4O10)HCID 67749512HCID 67749512, compound

Product 1

HCID 18977309HCID 18977309, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 6395Methanesulfonic AcidSolvent

Conditions

Temperature
70 °C

Procedure

A solution of phosphorous pentoxide (1.17 g, 8.21 mmole) in methanesulfonic acid (14.38 g) is treated with 2-[4-(trifluoromethoxy)phenoxy]fumaric acid (2.00 g, 6.85 mmole), stirred for 16-18 hours at ambient temperatures and for 7 hours at 70° C., cooled to room temperature and poured onto ice. The resultant mixture is filtered and the filtercake is dried to afford the title product, 1.75 g, (93% yield), mp 192°-194° C., identified by 1H and 13CNMR, IR, mass spectral and elemental analyses.

Workup

  1. temperaturecooled to room temperature
  2. additionpoured onto ice
  3. filtrationThe resultant mixture is filtered
  4. customthe filtercake is dried

Sources & evidence

ORD record
ord-352c6ab0c4824cb991b2b2f59de3777b
Source dataset
uspto-grants-1997_10
Patent number
US05681968

Reaction notes

Loading…