(3,4-Dimethoxyphenyl)acetic acid → HCID 54451967, compound

HRID 1490333Notes

Reaction equation

HRID 1490333 reaction equation
[C:1](O)(=O)[CH2:2][C:3]1[CH:12]=[CH:11][C:8]([O:9][CH3:10])=[C:5]([O:6][CH3:7])[CH:4]=1.[C:15]([O-:18])(=[O:17])C.[Na+]>>[CH3:7][O:6][C:5]1[CH:4]=[C:3]2[C:12](=[CH:11][C:8]=1[O:9][CH3:10])[C:15](=[O:17])[O:18][C:2]2=[CH:1][C:3]1[CH:12]=[CH:11][CH:8]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 7139(3,4-Dimethoxyphenyl)acetic acidHCID 517045Sodium Acetate

Product 1

HCID 54451967HCID 54451967, compound

Procedure

In a 25 ml flask were charged 4.0 g of m-hemipinic anhydride, 4.54 g of homoveratric acid, and sodium acetate, and the flask was buried in a sand bath at 235° to 240° C. to allow the mixture to react for 6 hours. The reaction mixture was purified by silica gel column chromatography (dichloromethane) to yield the title compound as a colorless amorphous compound.

Workup

  1. customthe flask was buried in a sand bath at 235° to 240° C.
  2. customto react for 6 hours
  3. customThe reaction mixture was purified by silica gel column chromatography (dichloromethane)

Sources & evidence

ORD record
ord-d7e4e4a3e0944908870eec8f3c64feab
Source dataset
uspto-grants-1997_10
Patent number
US05681954

Reaction notes

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