HCID 21481038, compound → HCID 54167170, compound

HRID 1490343Notes

Reaction equation

HRID 1490343 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([NH:23][C:24]([CH2:26][CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29])=[O:25])[C:18]=2[CH3:33])[CH2:13][CH2:12]1)=O)C1C=CC=CC=1.[H][H]>CO.[Pd]>[CH2:31]([O:30][C:28]([CH2:27][CH2:26][C:24]([NH:23][C:19]1[C:18]([CH3:33])=[C:17]([N:14]2[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]2)[CH:22]=[CH:21][CH:20]=1)=[O:25])=[O:29])[CH3:32]

Participants

5

Reactant 2

HCID 21481038HCID 21481038, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 54167170HCID 54167170, compoundYield 93.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

In 50 ml of methanol was dissolved 1.50 g of 1-benzyloxycarbonyl-4-(3-(2-ethoxycarbonylethyl)carbonylamino-2-methylphenyl)piperazine, and 1.0 g of 10% palladium-on-carbon was added thereto, followed by stirring at room temperature in a hydrogen atmosphere for 2 hours. The reaction mixture was filtered and the solvent was evaporated to yield 0.99 g of 3-(2-ethoxycarbonylethyl)carbonylamino-2-methylphenylpiperazine, which was used in the next reaction without purification.

Workup

  1. additionwas added
  2. filtrationThe reaction mixture was filtered
  3. customthe solvent was evaporated

Sources & evidence

ORD record
ord-86c12686655d455799c050cc98b8c30d
Source dataset
uspto-grants-1997_10
Patent number
US05681954

Reaction notes

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