Hydrochloric Acid → HCID 178486620, compound

HRID 1490344Notes

Reaction equation

HRID 1490344 reaction equation
[Cl:1][C:2]1[C:3]([CH3:35])=[C:4]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][C:16]3[C:24]4[C:19](=[CH:20][C:21]([O:27][CH3:28])=[C:22]([O:25][CH3:26])[CH:23]=4)[N:18]([CH2:29][C:30]4[N:31]=[CH:32][NH:33][CH:34]=4)[N:17]=3)[CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.[ClH:36]>O>[ClH:1].[ClH:36].[Cl:1][C:2]1[C:3]([CH3:35])=[C:4]([N:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][C:16]3[C:24]4[C:19](=[CH:20][C:21]([O:27][CH3:28])=[C:22]([O:25][CH3:26])[CH:23]=4)[N:18]([CH2:29][C:30]4[N:31]=[CH:32][NH:33][CH:34]=4)[N:17]=3)[CH2:12][CH2:13]2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178486619HCID 178486619, compound

Product 1

HCID 178486620HCID 178486620, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 4.95 g of 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole and 20 ml of 1N hydrochloric acid was stirred and to the mixture was added water till the overall volume reached to 49.5 ml. The suspension was refluxed with stirring till the mixture turned to a clear solution. After cooling to, room temperature, the solution was stirred at that temperature for overnight. A precipitated crystal was collected by filtration. The crystal was dried under atmospheric pressure for two days to yield 5.5 g of the titled compound as a colorless prism.

Workup

  1. temperatureThe suspension was refluxed
  2. stirringwith stirring till the mixture
  3. stirringthe solution was stirred at that temperature for overnight
  4. filtrationA precipitated crystal was collected by filtration
  5. customThe crystal was dried under atmospheric pressure for two days

Sources & evidence

ORD record
ord-0faabef669064f42a82176801f855b6c
Source dataset
uspto-grants-1997_10
Patent number
US05681954

Reaction notes

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