4-Fluorophenol → HCID 56737712, compound

HRID 1490700Notes

Reaction equation

HRID 1490700 reaction equation
Oc1ccc(F)cc1>C1=CCCC=CCC1.C1=CCCC=CCC1.C1CCCCC1.CC(C)(C)c1ccnc(-c2cc(C(C)(C)C)ccn2)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CC1(C)OBOC1(C)C.C[OH2+].C[OH2+].[Ir].[Ir]>CC1(C)OB(c2cc(F)ccc2O)OC1(C)C.CC1(C)OB(c2cc(O)ccc2F)OC1(C)C

Participants

8

Reactant 1

HCID 97324-Fluorophenol

Product 2

HCID 567377034-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenolYield 10%HCID 56737712HCID 56737712, compoundYield 90%

Reagents, catalysts & solvents 5

HCID 2733548Bis(pinacolato)diboraneReagentHCID 27347684,4,5,5-Tetramethyl[1,3,2]dioxaborolaneReagentHCID 42491874,4'-Di-tert-butyl-2,2'-bipyridylReagentHCID 76001521Bis(1,5-cyclooctadiene)dimethoxydiiridiumCatalystHCID 8078CyclohexaneSolvent

Conditions

Temperature
80 °C

Sources & evidence

ORD record
ord-58658a89ec3a40ce921de2606b3c01f7
Source dataset
Borylation dataset from Roche

Reaction notes

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