HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(tert-Butoxycarbonyl)azetidine → 1-Azetidinecarboxylic acid, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(tert-Butoxycarbonyl)azetidine | HCID 11205910 | — |
| Reagent | Bis(pinacolato)diborane | HCID 2733548 | — |
| Reagent | 2-Methyl-1,10-phenanthroline | HCID 4913356 | — |
| Catalyst | Bis(1,5-cyclooctadiene)dimethoxydiiridium | HCID 76001521 | — |
| Solvent | Cyclooctane | HCID 9266 | — |
| Product | 1-Azetidinecarboxylic acid, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester | HCID 118992045 | 51% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Provenance & Evidence
| DOI | 10.1126/science.aba6146 |
|---|---|
| Source dataset | Borylation dataset from Roche |
| ORD ID | ord-823e3b40e1b94c91b06c91aacdefd398 |
| Source note | Borylation dataset from Roche |