2,2-dimethyl-3-phenyl-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]propanamide → HCID 178438271, compound

HRID 1491090Notes

Reaction equation

HRID 1491090 reaction equation
CC(C)(Cc1ccccc1)C(=O)Nc1c(F)c(F)c(C(F)(F)F)c(F)c1F>CC#N.CC(=O)O.CC(=O)O.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CC[N+](CC)(CC)CC.COc1cc(OC)c2ccccc2n1.F[B-](F)(F)F.O=C(O)O.[K].[Pd]>CC(CB1OC(C)(C)C(C)(C)O1)(Cc1ccccc1)C(=O)Nc1c(F)c(F)c(C(F)(F)F)c(F)c1F

Participants

9

Reactant 1

HCID 1350770442,2-dimethyl-3-phenyl-N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]propanamide

Product 1

HCID 178438271HCID 178438271, compoundYield 77%

Reagents, catalysts & solvents 7

HCID 176Acetic AcidReagentHCID 1424362,4-DimethoxyquinolineReagentHCID 2724277Tetraethylammonium tetrafluoroborateReagentHCID 2733548Bis(pinacolato)diboraneReagentHCID 45051578carbonic acid, potassium saltReagentHCID 587591933375-31-3CatalystHCID 6342AcetonitrileSolvent

Conditions

Temperature
80 °C

Sources & evidence

ORD record
ord-e4305e6b5dfb41ec99bb8dae428f38fa
Source dataset
Borylation dataset from Roche

Reaction notes

Loading…