HCID 101499866, compound → HCID 178440530, compound

HRID 1491098Notes

Reaction equation

HRID 1491098 reaction equation
CC(C)(C)C(=O)Nc1c(F)c(F)c(C(F)(F)F)c(F)c1F>CC#N.CC(=O)O.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COc1cc(OC)c2ccccc2n1.O=C(O)O.[K].[Pd]>CC(C)(CB1OC(C)(C)C(C)(C)O1)C(=O)Nc1c(F)c(F)c(C(F)(F)F)c(F)c1F

Participants

7

Reactant 1

HCID 101499866HCID 101499866, compound

Product 1

HCID 178440530HCID 178440530, compoundYield 67%

Reagents, catalysts & solvents 5

HCID 1424362,4-DimethoxyquinolineReagentHCID 2733548Bis(pinacolato)diboraneReagentHCID 45051578carbonic acid, potassium saltReagentHCID 58759193palladium(I) acetateCatalystHCID 6342AcetonitrileSolvent

Conditions

Temperature
80 °C

Sources & evidence

ORD record
ord-580add60ba9d428898162a9a4efd0fca
Source dataset
Borylation dataset from Roche

Reaction notes

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