HCID 135072145, compound → HCID 178431033, compound

HRID 1491119Notes

Reaction equation

HRID 1491119 reaction equation
O=C(Nc1c(F)c(F)c(C(F)(F)F)c(F)c1F)C1CCCCC1>CC#N.CC(=O)O.CC(=O)O.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CC[N+](CC)(CC)CC.COc1cc(OC)c2ccccc2n1.F[B-](F)(F)F.O=C(O)O.[K].[Pd]>CC1(C)OB(C2CCCCC2C(=O)Nc2c(F)c(F)c(C(F)(F)F)c(F)c2F)OC1(C)C

Participants

9

Reactant 1

HCID 135072145HCID 135072145, compound

Product 1

HCID 178431033HCID 178431033, compound2×Yield 35%

Reagents, catalysts & solvents 7

HCID 176Acetic AcidReagentHCID 1424362,4-DimethoxyquinolineReagentHCID 2724277Tetraethylammonium tetrafluoroborateReagentHCID 2733548Bis(pinacolato)diboraneReagentHCID 45051578carbonic acid, potassium saltReagentHCID 58759193palladium(I) acetateCatalystHCID 6342AcetonitrileSolvent

Conditions

Temperature
80 °C

Sources & evidence

ORD record
ord-b21dab498fdf4ef9bbad76f9008d3cc9
Source dataset
Borylation dataset from Roche

Reaction notes

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