HCID 178489638, compound → HCID 178489639, compound

HRID 1491120Notes

Reaction equation

HRID 1491120 reaction equation
COc1cccc(C23CCC(C(=O)Nc4c(F)c(F)c(C(F)(F)F)c(F)c4F)(CC2)CO3)c1>CC#N.CC(=O)O.CC(=O)O.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CC[N+](CC)(CC)CC.COc1cc(OC)c2ccccc2n1.F[B-](F)(F)F.O=C(O)O.[K].[Pd]>COc1cccc(C23CCC(C(=O)Nc4c(F)c(F)c(C(F)(F)F)c(F)c4F)(CO2)C(B2OC(C)(C)C(C)(C)O2)C3)c1

Participants

9

Reactant 1

HCID 178489638HCID 178489638, compound

Product 1

HCID 178489639HCID 178489639, compound2×Yield 30%

Reagents, catalysts & solvents 7

HCID 176Acetic AcidReagentHCID 1424362,4-DimethoxyquinolineReagentHCID 2724277Tetraethylammonium tetrafluoroborateReagentHCID 2733548Bis(pinacolato)diboraneReagentHCID 45051578carbonic acid, potassium saltReagentHCID 58759193palladium(I) acetateCatalystHCID 6342AcetonitrileSolvent

Conditions

Temperature
80 °C

Sources & evidence

ORD record
ord-9229d3cffa0c48a8b83037dfb54d36bb
Source dataset
Borylation dataset from Roche

Reaction notes

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