HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1491132Generated: October 26, 2026
1-Methoxy-4-(methylthio)benzene → 2-(5-Methoxy-2-methylsulfanylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
https://huagongshe.com/reaction/1491132
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Methoxy-4-(methylthio)benzene | HCID 15885 | — |
| Reagent | Bis(pinacolato)diborane | HCID 2733548 | — |
| Reagent | 2-Pyridin-2-yl-5-[2-[4-(trifluoromethyl)-1,3,2-dioxaborolan-2-yl]phenyl]pyridine | HCID 134956623 | — |
| Catalyst | Bis(1,5-cyclooctadiene)dimethoxydiiridium | HCID 76001521 | — |
| Solvent | P-Xylene | HCID 7809 | — |
| Product | 2-(5-Methoxy-2-methylsulfanylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 132510260 | 66% |
Reaction Steps
Ligand 3f: A mixture of ortho- and meta-borylated products (92 mg, 66% yield, ortho/meta + para = >20); ortho-borylated product 4c was obtained by further purification by GPC (70 mg, 50% yield), white solid (mp. 71-73 oC)
Provenance & Evidence
| DOI | 10.1002/anie.201610041 |
|---|
| Source dataset | Borylation dataset from Roche |
|---|
| ORD ID | ord-2aa42d9e8bac447fb49a48f178396241 |
|---|
| Source note | Borylation dataset from Roche |
|---|
