HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1491164Generated: November 1, 2026
3-(Methylsulfanyl)benzonitrile → HCID 132510265, compound
https://huagongshe.com/reaction/1491164
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-(Methylsulfanyl)benzonitrile | HCID 13032813 | — |
| Reagent | Bis(pinacolato)diborane | HCID 2733548 | — |
| Reagent | 2-Pyridin-2-yl-5-[2-[4-(trifluoromethyl)-1,3,2-dioxaborolan-2-yl]phenyl]pyridine | HCID 134956623 | — |
| Catalyst | Bis(1,5-cyclooctadiene)dimethoxydiiridium | HCID 76001521 | — |
| Solvent | P-Xylene | HCID 7809 | — |
| Product | HCID 132510265 | HCID 132510265 | 75% |
Reaction Steps
Ligand 3f: A mixture of ortho- and meta-borylated products (103 mg, 75% yield, ortho/meta + para = >30); ortho-borylated product 4s was obtained by further purification by GPC (74 mg, 54% yield), white solid (mp. 68-70 oC)
Provenance & Evidence
| DOI | 10.1002/anie.201610041 |
|---|
| Source dataset | Borylation dataset from Roche |
|---|
| ORD ID | ord-edfe19ba5180435f820b5dac1dc46cd3 |
|---|
| Source note | Borylation dataset from Roche |
|---|
