HCID 53329571, compound → HCID 135058004, compound

HRID 1491212Notes

Reaction equation

HRID 1491212 reaction equation
Cc1ccccc1C(=O)Nc1c(F)c(F)c(C(F)(F)F)c(F)c1F>CC#N.CC(=O)O.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1ccc(S(=O)(=O)O)cc1.O=C(C=Cc1ccc(C(F)(F)F)cc1)C=Cc1ccc(C(F)(F)F)cc1.O=S(=O)(O)OOS(=O)(=O)O.[K].[Na].[Pd]>Cc1cccc(B2OC(C)(C)C(C)(C)O2)c1C(=O)Nc1c(F)c(F)c(C(F)(F)F)c(F)c1F

Participants

8

Reactant 1

HCID 53329571HCID 53329571, compound

Product 1

HCID 135058004HCID 135058004, compoundYield 85%

Reagents, catalysts & solvents 6

HCID 5922411,5-Bis[4-(trifluoromethyl)phenyl]penta-1,4-dien-3-oneReagentHCID 2733548Bis(pinacolato)diboraneReagentHCID 24195884Sodium p-toluenesulfonateReagentHCID 43835029CID 43835029ReagentHCID 58759193palladium(I) acetateCatalystHCID 6342AcetonitrileSolvent

Conditions

Temperature
80 °C

Sources & evidence

ORD record
ord-7d091afe69114ad4bda47e48c0bad6e7
Source dataset
Borylation dataset from Roche

Reaction notes

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