HCID 135075322, compound → HCID 135058341, compound

HRID 1491222Notes

Reaction equation

HRID 1491222 reaction equation
COc1cccc(C(=O)Nc2c(F)c(F)c(C(F)(F)F)c(F)c2F)c1>CC#N.CC(=O)O.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1ccc(S(=O)(=O)O)cc1.O=C(C=Cc1ccc(C(F)(F)F)cc1)C=Cc1ccc(C(F)(F)F)cc1.O=S(=O)(O)OOS(=O)(=O)O.[K].[Na].[Pd]>COc1ccc(B2OC(C)(C)C(C)(C)O2)c(C(=O)Nc2c(F)c(F)c(C(F)(F)F)c(F)c2F)c1

Participants

8

Reactant 1

HCID 135075322HCID 135075322, compound

Product 1

HCID 135058341HCID 135058341, compoundYield 62%

Reagents, catalysts & solvents 6

HCID 5922411,5-Bis[4-(trifluoromethyl)phenyl]penta-1,4-dien-3-oneReagentHCID 2733548Bis(pinacolato)diboraneReagentHCID 24195884Sodium p-toluenesulfonateReagentHCID 43835029CID 43835029ReagentHCID 58759193palladium(I) acetateCatalystHCID 6342AcetonitrileSolvent

Conditions

Temperature
80 °C

Sources & evidence

ORD record
ord-327c5e3b1ee14cda8cc57298b8f0747a
Source dataset
Borylation dataset from Roche

Reaction notes

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