反应详情

温度

0 °C

Methane sulphonyl chloride (7.0 g) was added to a stirred, cooled mixture of methyl 4-chlorosalicylate (10.0 g) and triethylamine (8.0 g) in dichloromethane while maintaining the temperature at 0° C. The mixture was then stirred at room temperature for one-half hour and left to stand overnight. The mixture was washed with hydrochloric acid (2M), saturated aqueous sodium bicarbonate solution, water, dried (Na2SO4) and filtered. The filtrate was evaporated to dryness to give methyl 4-chloro-2-(methylsulphonyloxy)benzoate (11.7 g) as an orange solid m.p. 82.5°-84.5° C.

1. temperaturecooled
2. waitleft
3. washThe mixture was washed with hydrochloric acid (2M), saturated aqueous sodium bicarbonate solution, water
4. dry with materialdried (Na2SO4)
5. filtrationfiltered
6. customThe filtrate was evaporated to dryness