HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1491581Generated: November 1, 2026
m-Chloroperbenzoic acid → Methyl 3-fluoro-2-methylsulphonylbenzoate
https://huagongshe.com/reaction/1491581
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | Sodium Pyrosulfite | HCID 656671 | — |
| Reactant | Methyl 3-fluoro-2-(methylthio)benzoate | HCID 18953297 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 3-fluoro-2-methylsulphonylbenzoate | HCID 18953324 | — |
Reaction Steps
A mixture of methyl 3-fluoro-2-methylsulphenylbenzoate (14.0 g) and 3-chloroperbenzoic acid (50-60%, 55.0 g) in dichloromethane was stirred at 25° C. for 1.5 hours. 1M Sodium metabisulphite was added and the organic phase washed with sodium bicarbonate and brine, dried over sodium sulphate, filtered and evaporated. The product was recrystallised from ethyl acetate to give 8.6 g of methyl 3-fluoro-2-methylsulphonylbenzoate as white crystals, m.p. 116.2° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05371064 |
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| Source dataset | uspto-grants-1994_12 |
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| ORD ID | ord-97a009b276364dcc8a1f7d05e2ee5542 |
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| Source note | uspto-grants-1994_12 |
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