反应详情

温度

25 °C

A mixture of methyl 3-fluoro-2-methylsulphenylbenzoate (14.0 g) and 3-chloroperbenzoic acid (50-60%, 55.0 g) in dichloromethane was stirred at 25° C. for 1.5 hours. 1M Sodium metabisulphite was added and the organic phase washed with sodium bicarbonate and brine, dried over sodium sulphate, filtered and evaporated. The product was recrystallised from ethyl acetate to give 8.6 g of methyl 3-fluoro-2-methylsulphonylbenzoate as white crystals, m.p. 116.2° C.

1. washthe organic phase washed with sodium bicarbonate and brine
2. dry with materialdried over sodium sulphate
3. filtrationfiltered
4. customevaporated
5. customThe product was recrystallised from ethyl acetate