反应详情

温度

0 °C

A mixture of 2-chloro-5-methyl-4-morpholino-quinazoline (1.68 g, 6.4 mmol) and 3-cyclopropyl-5-isocyanomethyl-1,2,4-oxadiazole (1.9 g) in 15 ml of dry dimethylformamide was cooled to 0° C. Solid potassium tert-butoxide (1.4 g, 12.5 mmol) was added gradually during 5 min. to the stirred mixture, the temperature being kept below 10° C. The mixture was stirred at ambient temperature for two hors, and then cooled to 0° C. The precipitated crystals were collected by filtration, rinsed on the filter with ethyl acetate and water, and dried to give the title compound as light yellow crystals, m.p. 262°-266° C. Yield 1.29 g.

1. custombeing kept below 10° C
2. temperaturecooled to 0° C
3. filtrationThe precipitated crystals were collected by filtration
4. washrinsed on the
5. filtrationfilter with ethyl acetate and water
6. customdried