2-(N-Ethoxycarbonyl-N-propargylaminomethyl)-pyrimidine → ethyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate

HRID 1491653Notes

Reaction equation

HRID 1491653 reaction equation
[CH2:1]([O:3][C:4]([N:6]([CH2:10][C:11]1[N:16]=[CH:15][CH:14]=[CH:13]N=1)[CH2:7][C:8]#C)=[O:5])[CH3:2]>C1(C)C(C)=CC=CC=1>[N:16]1[CH:15]=[CH:14][CH:13]=[C:8]2[CH2:7][N:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:10][C:11]=12

Participants

3

Reactant 1

HCID 189536422-(N-Ethoxycarbonyl-N-propargylaminomethyl)-pyrimidine

Product 1

HCID 18953634ethyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

7.7 g (35 mmol) of 2-(N-ethoxycarbonyl-N-propargyl-aminomethyl)-pyrimidine are refluxed for 40 hours in 150 ml of xylene. The mixture is concentrated, and the residue is recrystallised from ligroin.

Workup

  1. concentrationThe mixture is concentrated
  2. customthe residue is recrystallised from ligroin

Sources & evidence

ORD record
ord-5c741e4f24ee4f34ba6f0bb3a0ebed0e
Source dataset
uspto-grants-1994_12
Patent number
US05371090

Reaction notes

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