Hydrochloric Acid → 6,7-Dihydro-5H-pyrrolo[3,4-b]pyridine--hydrogen chloride (1/2)

HRID 1491654Notes

Reaction equation

HRID 1491654 reaction equation
[NH:1]1[CH2:6][CH:5]=[CH:4][C:3]2[CH2:7][N:8](C(OCC)=O)[CH2:9][C:2]1=2.[ClH:15]>>[ClH:15].[ClH:15].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]2[CH2:7][NH:8][CH2:9][C:2]=12

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 18953638HCID 18953638, compound

Product 1

HCID 235036166,7-Dihydro-5H-pyrrolo[3,4-b]pyridine--hydrogen chloride (1/2)

Procedure

8.5 g (44 mmol) of ethyl 5,7-dihydro-1H-pyrrolo-[3,4-b]pyridine-6-carboxylate are refluxed overnight in 90 ml of concentrated hydrochloric acid. The solution is concentrated, the residue is stirred with acetone, and the salt is filtered off with suction and dried in the air.

Workup

  1. concentrationThe solution is concentrated
  2. filtrationthe salt is filtered off with suction
  3. customdried in the air

Sources & evidence

ORD record
ord-52bf2b0ac6c541af9ab63afe10e76a1a
Source dataset
uspto-grants-1994_12
Patent number
US05371090

Reaction notes

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