反应详情

To a mixture of 4-(4-chlorophenyl)-2-oxazolepropionic acid (0.5 g) and isopropanol (30 ml) was added conc. sulfuric acid (0.3 ml), and the resultant was refluxed for 5 hours. The reaction mixture was poured into water and extracted with ether. The ether layer was washed succesively with a saturated sodium hydrogen carbonate aqueous solution and water, and dried over MgSO4. The ether was distilled off to give crystals of isopropyl 4-(4-chlorophenyl)-2-oxazolepropionate (530 mg, 91%). Recrystallization from hexane gave colorless prism crystals of mp 30°-31° C.

1. temperaturethe resultant was refluxed for 5 hours
2. extractionextracted with ether
3. washThe ether layer was washed succesively with a saturated sodium hydrogen carbonate aqueous solution and water
4. dry with materialdried over MgSO4
5. distillationThe ether was distilled off