反应详情

To a solution of 4-(4-chlorophenyl)-2-oxazoleproponic acid (1.5 g) in THF (20 ml) was added lithium aluminum hydride (0.27 g), followed by stirring for 3 hours at room temperature. Water (3 ml) was added to the reaction mixture. The resultant was extracted with ethyl acetate. The ethyl acetate layer was washed with 2N-HCl and water, dried over MgSO4, and distilled to remove the solvent. The oily residue was subjected to a silica gel chromatography. Crystals of 3-[4-(4-chlorophenyl)-2-oxazolyl]propanol (1.11 g, 78%) were obtained from the fraction eluted with ethyl acetate-hexane (2:1, V/V). Recrystallization from ether-hexane gave colorless prism crystals of mp 43°-44° C.

1. extractionThe resultant was extracted with ethyl acetate
2. washThe ethyl acetate layer was washed with 2N-HCl and water
3. dry with materialdried over MgSO4
4. distillationdistilled
5. customto remove the solvent