Pyrazole → HCID 15337561, compound

HRID 1491703Notes

Reaction equation

HRID 1491703 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@@H:12](O)[CH3:13])[CH2:11][O:10]1.[NH:15]1[CH:19]=[CH:18][CH:17]=[N:16]1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@H:12]([N:15]2[CH:19]=[CH:18][CH:17]=[N:16]2)[CH3:13])[CH2:11][O:10]1

Participants

3

Reactant 2

HCID 1048PyrazoleHCID 10631861(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol

Product 1

HCID 15337561HCID 15337561, compound

Procedure

Using (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol (569 mg) and pyrazole, (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-(1H-pyrazol-1-yl)ethyl]oxirane (166 mg) was obtained by the same way as in Reference Example 2.

Sources & evidence

ORD record
ord-334a6b3c676d40e9bf234927021065b3
Source dataset
uspto-grants-1994_12
Patent number
US05371100

Reaction notes

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