6-Chloropurine → HCID 57145125, compound

HRID 1491716Notes

Reaction equation

HRID 1491716 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@@H:12](O)[CH3:13])[CH2:11][O:10]1.[Cl:15][C:16]1[N:24]=[CH:23][N:22]=[C:21]2[C:17]=1[NH:18][CH:19]=[N:20]2>>[Cl:15][C:16]1[N:24]=[CH:23][N:22]=[C:21]2[C:17]=1[N:18]=[CH:19][N:20]2[C@@H:12]([C@@:9]1([C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[F:1])[CH2:11][O:10]1)[CH3:13]

Participants

3

Reactant 2

HCID 53592776-ChloropurineHCID 10631861(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol

Product 1

HCID 57145125HCID 57145125, compoundYield 47.9%

Procedure

Using (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl] ethanol (607 mg) and 6-chloropurine (422 mg), (2S)-2-[(1R)-1-[6-chloro-9(9H) -purinyl]ethyl]-2-(2,4-difluorophenyl) oxirane (440 mg) was obtained as a white powder by the same way as in Reference Example 2.

Sources & evidence

ORD record
ord-165d17dead1a4e7ba3937cbe11e644e5
Source dataset
uspto-grants-1994_12
Patent number
US05371100

Reaction notes

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