2,2-Diethoxyethylamine → HCID 10805622, compound

HRID 1491783Notes

Reaction equation

HRID 1491783 reaction equation
[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][NH2:6])[CH3:2].[F:10][C:11]([F:22])([F:21])[C:12]1[CH:17]=[CH:16][C:15]([N:18]=[C:19]=[O:20])=[CH:14][CH:13]=1>>[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][NH:6][C:19]([NH:18][C:15]1[CH:14]=[CH:13][C:12]([C:11]([F:10])([F:21])[F:22])=[CH:17][CH:16]=1)=[O:20])[CH3:2]

Participants

3

Reactant 2

HCID 695242,2-DiethoxyethylamineHCID 737684-(Trifluoromethyl)phenyl isocyanate

Product 1

HCID 10805622HCID 10805622, compoundYield 95%

Procedure

To aminoacetoaldehyde diethylacetal (7.8 ml, 53.6 mmol) was added dropwise 10 g (53.4 mmol) of 4-trifluoromethylphenylisocyanate at 0° C. during five minutes. The reaction solution was stirred for one hour at room temperature. The crystals thus produced was collected by filtration and washed with hexane to give 16.2 g of 1-(2,2-diethoxyethyl)-3-(4-trifluoromethylphenyl)urea (95%) as a colorless powder.

Workup

  1. customThe crystals thus produced
  2. filtrationwas collected by filtration
  3. washwashed with hexane

Sources & evidence

ORD record
ord-473aaf21843d4f81adcdc502eeda3cca
Source dataset
uspto-grants-1994_12
Patent number
US05371101

Reaction notes

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