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HRID1491818

反应详情

EQUATION

反应方程式

HRID 1491818 的结构方程式

REACTANTS

反应物

2
结构：CC(=O)NCC(N)=S
HCID4435531

N-(2-amino-2-thioxoethyl)acetamide

C4H8N2OS

结构：CC(=O)C(=O)CBr
HCID10953880

1-bromobutane-2,3-dione

C4H5BrO2

PRODUCTS

生成物

1
结构：CC(=O)NCc1nc(C(C)=O)cs1
HCID10012967

未命名化合物

收率 92.9%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

A suspension of 1-bromo-2,3-butanedione (47 g) and N-[(thiocarbamoyl)methyl]acetamide (30 g) in acetone (600 ml) was refluxed for 3 hours. The resulting precipitate was collected by filtration to afford 4-acetyl-2-(acetylaminomethyl)thiazole (41.8 g).

WORKUP

后处理

  1. temperaturewas refluxed for 3 hours
  2. filtrationThe resulting precipitate was collected by filtration