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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1491818Generated: October 26, 2026

N-(2-amino-2-thioxoethyl)acetamide → 4-Acetyl-2-(acetylaminomethyl)thiazole

https://huagongshe.com/reaction/1491818

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(2-amino-2-thioxoethyl)acetamideHCID 4435531—
Reactant1-Bromobutane-2,3-dioneHCID 10953880—
SolventAcetoneHCID 180—
Product4-Acetyl-2-(acetylaminomethyl)thiazoleHCID 1001296792.9%

Reaction Steps

A suspension of 1-bromo-2,3-butanedione (47 g) and N-[(thiocarbamoyl)methyl]acetamide (30 g) in acetone (600 ml) was refluxed for 3 hours. The resulting precipitate was collected by filtration to afford 4-acetyl-2-(acetylaminomethyl)thiazole (41.8 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05371097
Source datasetuspto-grants-1994_12
ORD IDord-af62075ef9174937b6c87169c1d6e6f8
Source noteuspto-grants-1994_12