6-(Hydroxymethyl)pyridine-2-carboxamide → HCID 18953918, compound

HRID 1491821Notes

Reaction equation

HRID 1491821 reaction equation
[OH:1][CH2:2][C:3]1[N:8]=[C:7]([C:9]([NH2:11])=[O:10])[CH:6]=[CH:5][CH:4]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH:2]([C:3]1[N:8]=[C:7]([C:9]([NH2:11])=[O:10])[CH:6]=[CH:5][CH:4]=1)=[O:1]

Participants

4

Reactant 1

HCID 149169816-(Hydroxymethyl)pyridine-2-carboxamide

Product 1

HCID 18953918HCID 18953918, compoundYield 61.3%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Procedure

A mixture of 6-hydroxymethyl-2-pyridinecarboxamide (100 g) and manganese dioxide (500 g) in chloroform (2 l) was heated under reflux for 48 hours. Manganese dioxide was removed by filtration and the filtrate was evaporated in vacuo to give 6-formyl-2-pyridinecarboxamide (60.46 g).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 48 hours
  3. customManganese dioxide was removed by filtration
  4. customthe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-0d14b8dd3316448dab3144b334b45322
Source dataset
uspto-grants-1994_12
Patent number
US05371097

Reaction notes

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