Chloride → HCID 18953934, compound

HRID 1491835Notes

Reaction equation

HRID 1491835 reaction equation
[C:1]([C:4]1[N:9]=[C:8]([C:10]([O:12][CH3:13])=[O:11])[CH:7]=[C:6]([Cl:14])[CH:5]=1)(=[O:3])[CH3:2].[Cl-:15]>C(O)(=O)C>[Cl:14][C:6]1[CH:5]=[C:4]([C:1](=[O:3])[CH2:2][Cl:15])[N:9]=[C:8]([C:10]([O:12][CH3:13])=[O:11])[CH:7]=1

Participants

4

Reactant 2

HCID 312ChlorideHCID 18953802HCID 18953802, compound

Product 1

HCID 18953934HCID 18953934, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of methyl 6-acetyl-4-chloro-2-pyridinecarboxylate (6.55 g) and surfuryl chloride (2,73 ml) in acetic acid (33 ml) was stirred at ambient temperature for 14 hours and further at 50° C. for three hours, The solvent was evaporated in vacuo and the residue was mixed with water. The resulting precipitate was collected by filtration and washed with water to give methyl 4-chloro-6-chloroacetyl-2-pyridinecarboxylate (6.75 g).

Workup

  1. customThe solvent was evaporated in vacuo
  2. additionthe residue was mixed with water
  3. filtrationThe resulting precipitate was collected by filtration
  4. washwashed with water

Sources & evidence

ORD record
ord-e654837034e84e8987d29644ad467972
Source dataset
uspto-grants-1994_12
Patent number
US05371097

Reaction notes

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