Hydrochloric Acid → 4-(2-Aminomethylthiazol-4-yl)-2-(diaminomethyleneamino)thiazole dihydrochloride

HRID 1491848Notes

Reaction equation

HRID 1491848 reaction equation
[ClH:1].C([NH:5][CH2:6][C:7]1[S:8][CH:9]=[C:10]([C:12]2[N:13]=[C:14]([N:17]=[C:18]([NH2:20])[NH2:19])[S:15][CH:16]=2)[N:11]=1)(=O)C>C(O)C>[ClH:1].[ClH:1].[NH2:5][CH2:6][C:7]1[S:8][CH:9]=[C:10]([C:12]2[N:13]=[C:14]([N:17]=[C:18]([NH2:20])[NH2:19])[S:15][CH:16]=2)[N:11]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 104023264-(2-Acetylaminomethylthiazol-4-yl)-2-(diaminomethyleneamino)thiazole

Product 1

HCID 189538344-(2-Aminomethylthiazol-4-yl)-2-(diaminomethyleneamino)thiazole dihydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Concentrated hydrochloric acid (72.4 ml) was added slowly to a suspension of 4-(2-acetylaminomethylthiazol-4-yl)-2-(diaminomethyleneamino)thiazole (6.58 g) in ethanol (280 ml). The mixture was refluxed for 2 hours. The resulting precipitate was collected by filtration. Recrystallization from a mixture of methanol and water afforded 4-(2-aminomethylthiazol-4-yl)-2(diaminomethyleneamino)thiazole dihydrochloride (6.98 g).

Workup

  1. temperatureThe mixture was refluxed for 2 hours
  2. filtrationThe resulting precipitate was collected by filtration
  3. customRecrystallization
  4. additionfrom a mixture of methanol and water

Sources & evidence

ORD record
ord-32a52234fb7b45e09440b505b5a0c158
Source dataset
uspto-grants-1994_12
Patent number
US05371097

Reaction notes

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