HCID 18953815, compound → HCID 18953827, compound

HRID 1491853Notes

Reaction equation

HRID 1491853 reaction equation
[NH2:1][C:2](=[N:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[N:11]=[C:12]([C:15]([NH2:17])=[O:16])[S:13][CH:14]=2)[N:9]=1)[NH2:3].[ClH:18].O1CCOCC1>CO>[ClH:18].[NH2:1][C:2](=[N:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[N:11]=[C:12]([C:15]([NH2:17])=[O:16])[S:13][CH:14]=2)[N:9]=1)[NH2:3]

Participants

4

Reactant 2

HCID 18953815HCID 18953815, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 18953827HCID 18953827, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 4-[2-(diaminomethyleneamino)thiazol-4-yl ]thiazole-2-carboxamide (1.0 g) in 4N-hydrogenchloride/dioxane (1.0 ml) and methanol (10 ml) was stirred for 1 hour at room temperature. The resulting precipitate was collected by filtration. Recrystallization from water afforded 4-[2-(diaminomethyleneamino)thiazol-4-yl)thiazole-2-carboxamide hydrochloride (850 mg).

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. customRecrystallization from water

Sources & evidence

ORD record
ord-fe1c5d6e612d4f2a8ea845d384b20d09
Source dataset
uspto-grants-1994_12
Patent number
US05371097

Reaction notes

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