Hydrazine hydrate (1:1) → HCID 10060571, compound

HRID 1491890Notes

Reaction equation

HRID 1491890 reaction equation
[NH2:1][C:2](=[N:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][N:13]=[C:12]([CH2:16][N:17]3C(=O)C4=CC=CC=C4C3=O)[CH:11]=2)[N:9]=1)[NH2:3].O.NN>C(O)C>[NH2:17][CH2:16][C:12]1[CH:11]=[C:10]([C:8]2[N:9]=[C:5]([N:4]=[C:2]([NH2:3])[NH2:1])[S:6][CH:7]=2)[CH:15]=[CH:14][N:13]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 10474781HCID 10474781, compound

Product 1

HCID 10060571HCID 10060571, compoundYield 97.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-(diaminomethyleneamino)-4-(2-phthalimidomethylpyridin-4-yl)thiazole (1.57 g) and hydrazine hydrate (0.63 g) in ethanol (25 ml) was refluxed for two hours. The resulting precipitate was filtered off and washed with methanol (20 ml). The two organic layer was combined and evaporated in vacuo to give 4-(2-aminomethylpyridin-4-yl)-2-(diaminomethyleneamino)thiazole (1.00 g).

Workup

  1. temperaturewas refluxed for two hours
  2. filtrationThe resulting precipitate was filtered off
  3. washwashed with methanol (20 ml)
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-9810f9b6075341179ebcf2cfa5885de8
Source dataset
uspto-grants-1994_12
Patent number
US05371097

Reaction notes

Loading…