Ammonia → HCID 18953852, compound

HRID 1491893Notes

Reaction equation

HRID 1491893 reaction equation
[NH2:1][C:2](=[N:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[CH:11]=[N:12][CH:13]=[C:14]([C:16]([O:18]C)=O)[CH:15]=2)[N:9]=1)[NH2:3].[NH3:20]>O1CCCC1>[C:16]([C:14]1[CH:15]=[C:10]([C:8]2[N:9]=[C:5]([N:4]=[C:2]([NH2:3])[NH2:1])[S:6][CH:7]=2)[CH:11]=[N:12][CH:13]=1)(=[O:18])[NH2:20]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 104687342-(Diaminomethyleneamino)-4-(5-methoxycarbonylpyridin-3-yl)thiazole

Product 1

HCID 18953852HCID 18953852, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A suspension of 2-(diaminomethyleneamino)-4-(5-methoxycarbonylpyridin-3-yl)thiazole (500 mg) in 28% ammonia solution (15 ml) and tetrahydrofuran (15 ml) was stirred at room temperature for 9.5 hours. The solvent was removed under reduced pressure. The residue was washed with methanol to afford 4-(5-carbamoylpyridin-3-yl)-2-(diaminomethyleneamino)thiazole (350 mg).

Workup

  1. customThe solvent was removed under reduced pressure
  2. washThe residue was washed with methanol

Sources & evidence

ORD record
ord-aff8b5c92e1a48c9a0ac2085addaa82c
Source dataset
uspto-grants-1994_12
Patent number
US05371097

Reaction notes

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