HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Methoxyphenyl)piperazine → HCID 14856131, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Methoxyphenyl)piperazine | HCID 1346 | — |
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-(4-Bromobutyl)-4-thiazolidinone | HCID 10847505 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 14856131 | HCID 14856131 | 79.3% |
Reaction Steps
A suspension of 3-(4-bromobutyl)-4-thiazolidinone (3.0 g), 1-(2-methoxyphenyl)piperazine (2.43 g), anhydrous K2CO3 (3 g) and NaI (200 mg) in 100 ml of anhydrous CH3CN was heated to reflux under N2. After 18 hours the mixture was cooled to room temperature and filtered. The filtrate was concentrated in vacuo, and the residue taken up and chromatographed (silica, EtOAc eluent) to provide 3.49 g of product as a white solid, mp 80°-81° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05371087 |
| Source dataset | uspto-grants-1994_12 |
| ORD ID | ord-9345647282664b7aaf95b6d089f1b8ac |
| Source note | uspto-grants-1994_12 |