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Sodium Iodide → 3-[4-[1-(3-Chlorophenyl)-4-piperazinyl]butyl]-4-thiazolidinone hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-(2-Chlorophenyl)piperazine dihydrochloride | HCID 3018683 | — |
| 反応物 | 3-(4-Bromobutyl)-4-thiazolidinone | HCID 10847505 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 3-[4-[1-(3-Chlorophenyl)-4-piperazinyl]butyl]-4-thiazolidinone hydrochloride | HCID 14856136 | — |
反応手順
To a solution of 3-(4-bromobutyl)-4-thiazolidinone (3.0 g) and 1-(2-chlorophenyl)piperazine dihydrochloride (3.4 g) in 100 ml of anhydrous CH3CN were added K2CO3 (8.7 g) and NaI (200 mg). The mixture was heated at 80° with stirring under N2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05371087 |
| 出典データセット | uspto-grants-1994_12 |
| ORD ID | ord-485b40b7969b4774b2a23ce3e7d26292 |
| 出典メモ | uspto-grants-1994_12 |