Sodium Iodide → HCID 14856136, compound

HRID 1491904Notes

Reaction equation

HRID 1491904 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:10](=[O:11])[CH2:9][S:8][CH2:7]1.[ClH:12].Cl.[Cl:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1.C([O-])([O-])=O.[K+].[K+].[Na+].[I-]>CC#N>[ClH:14].[Cl:12][C:20]1[CH:15]=[C:16]([N:21]2[CH2:26][CH2:25][N:24]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]3[C:10](=[O:11])[CH2:9][S:8][CH2:7]3)[CH2:23][CH2:22]2)[CH:17]=[CH:18][CH:19]=1

Participants

6

Reactant 4

HCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 30186831-(2-Chlorophenyl)piperazine dihydrochlorideHCID 108475053-(4-Bromobutyl)-4-thiazolidinone

Product 1

HCID 14856136HCID 14856136, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 3-(4-bromobutyl)-4-thiazolidinone (3.0 g) and 1-(2-chlorophenyl)piperazine dihydrochloride (3.4 g) in 100 ml of anhydrous CH3CN were added K2CO3 (8.7 g) and NaI (200 mg). The mixture was heated at 80° with stirring under N2.

Workup

  1. temperatureThe mixture was heated at 80°

Sources & evidence

ORD record
ord-485b40b7969b4774b2a23ce3e7d26292
Source dataset
uspto-grants-1994_12
Patent number
US05371087

Reaction notes

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