HCID 178435512, compound → HCID 178435511, compound

HRID 1491964Notes

Reaction equation

HRID 1491964 reaction equation
[CH2:1]([C:3]1[CH:12]=[C:11]2[C:6]([C:7]([CH3:42])=[C:8]([CH2:32][C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=3[N+:39]([O-])=O)[C:9](=[O:31])[N:10]2[CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:16][CH:15]=2)=[CH:5][CH:4]=1)[CH3:2]>C(O)C>[NH2:39][C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=1[CH2:32][C:8]1[C:9](=[O:31])[N:10]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:16][CH:15]=2)[C:11]2[C:6]([C:7]=1[CH3:42])=[CH:5][CH:4]=[C:3]([CH2:1][CH3:2])[CH:12]=2

Participants

3

Reactant 1

HCID 178435512HCID 178435512, compound

Product 1

HCID 178435511HCID 178435511, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 1 g of 7-ethyl-1,2-dihydro-4-methyl-3-o-nitrobenzyl-2-oxo-1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]quinoline in 25 ml of ethanol is hydrogenated on 0.3 g of 5% Pd-on-charcoal at 20° and normal pressure until the calculated amount of H2 has been taken up. The catalyst is filtered off, the filtrate is evaporated and the 3-o-aminobenzyl-7-ethyl-1,2-dihydro-4-methyl-2-oxo-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl-methyl]quinoline obtained is purified by chromatography.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe filtrate is evaporated

Sources & evidence

ORD record
ord-3b4b001e43164052b683d9a016e2e677
Source dataset
uspto-grants-1994_12
Patent number
US05371226

Reaction notes

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