Methylamine → HCID 19429849, compound

HRID 1491976Notes

Reaction equation

HRID 1491976 reaction equation
C[O:2][C:3](=O)/[C:4](/[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][C:15]1[CH:16]=[C:17]([CH3:21])[CH:18]=[CH:19][CH:20]=1)=[N:5]\[O:6][CH3:7].[CH3:23][NH2:24]>>[CH3:23][NH:24][C:3](=[O:2])/[C:4](/[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][C:15]1[CH:16]=[C:17]([CH3:21])[CH:18]=[CH:19][CH:20]=1)=[N:5]\[O:6][CH3:7]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 15764703HCID 15764703, compound

Product 1

HCID 19429849HCID 19429849, compound

Procedure

To Product (A') (286 mg), i.e. methyl-(Z)-2-[ 2-(3-tolyloxy) phenyl]-2-methoxyiminoacetate, 30% methanolic methylamine (197 mg) was added, followed by stirring at room temperature for 12 hours. Excess amine and methanol were removed from the mixture, which was subjected to silica gel column chromatography with a mixture of hexane and ethyl acetate to give 201 mg of (Z)-N-methyl-2-[2-(3 -tolyloxy) phenyl]-2-methoxyiminoacetamide (Compound No. 5 ).

Workup

  1. customExcess amine and methanol were removed from the mixture, which
  2. additionwas subjected to silica gel column chromatography with a mixture of hexane and ethyl acetate

Sources & evidence

ORD record
ord-84f5c3520e9f4e1b9672e07995e2cb01
Source dataset
uspto-grants-1994_12
Patent number
US05371222

Reaction notes

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