Trifluoroacetic acid → 104131-82-0

HRID 1492077Notes

Reaction equation

HRID 1492077 reaction equation
[CH2:1]([C:4]1([C:7]([O:9]C(C)(C)C)=[O:8])[CH2:6][CH2:5]1)[CH2:2][CH3:3].FC(F)(F)C(O)=O>[OH-].[Na+]>[CH2:1]([C:4]1([C:7]([OH:9])=[O:8])[CH2:6][CH2:5]1)[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 14996285HCID 14996285, compound

Product 1

HCID 13707476104131-82-0Yield 95%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A stirred mixture of 21.0 g (0.11 mol) of tertbutyl 1-n-propylcyclopropanecarboxylate and 13.0 g (0.11 mol) of trifluoroacetic acid was refluxed for 3 hours and then added to 20 ml of dilute sodium hydroxide solution. After extraction of the byproducts with diethyl ether, the aqueous phase was acidified with dilute hydrochloric acid and again extracted with diethyl ether. This ether phase was then worked up in a conventional manner to obtain the product. Yield: 95%; colorless oil.

Workup

  1. temperaturewas refluxed for 3 hours
  2. extractionAfter extraction of the byproducts with diethyl ether
  3. extractionagain extracted with diethyl ether
  4. customto obtain the product

Sources & evidence

ORD record
ord-b24aaf9051bb420dafbdcd20225dd42e
Source dataset
uspto-grants-1994_12
Patent number
US05371268

Reaction notes

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