Potassium Hydroxide → HCID 67824007, compound

HRID 1492081Notes

Reaction equation

HRID 1492081 reaction equation
[F:1][C:2]1[CH:14]=[CH:13][C:5]([CH2:6][C:7]2(C(O)=O)[CH2:9][CH2:8]2)=[CH:4][CH:3]=1.[OH-].[K+].[K].F[CH:19]1[CH2:21][C:20]1(CC1C=CC=CC=1)[C:22]([OH:24])=[O:23].BrC[C:34]1[CH:39]=[CH:38]C=C[C:35]=1[C:40](=[CH:45][O:46][CH3:47])[C:41]([O:43][CH3:44])=[O:42]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH:7]([O:24][C:22]([CH:20]2[CH2:19][CH2:21]2)=[O:23])[C:9]2[CH:8]=[CH:38][CH:39]=[CH:34][C:35]=2[C:40](=[CH:45][O:46][CH3:47])[C:41]([O:43][CH3:44])=[O:42])=[CH:13][CH:14]=1

Participants

6

Reactant 5

HCID 14797Potassium HydroxideHCID 5462222PotassiumHCID 14996290HCID 14996290, compoundHCID 53395349Methyl 2-[2-(bromomethyl)phenyl]-3-methoxyprop-2-enoateHCID 54373368HCID 54373368, compound

Product 1

HCID 67824007HCID 67824007, compoundYield 54%

Procedure

A method similar to Example 3 was used and 6.3 g (32 mmol) of 1-(4-fluorobenzyl)-cyclopropanecarboxylic acid were converted with 2.0 g (36 mmol) of potassium hydroxide into the potassium salt of fluorobenzylcyclopropanecarboxylic acid, and said salt was then reacted at 100° C. with 6.3 g (22 mmol) of methyl alpha-(2-bromomethylphenyl)-beta-methoxyacrylate. Yield: 54%; colorless oil.

Sources & evidence

ORD record
ord-b6c831a1951b46ad915d278c54630782
Source dataset
uspto-grants-1994_12
Patent number
US05371268

Reaction notes

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