Methyl iodide → HCID 18952092, compound

HRID 1492154Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([S:16][C:17]2[CH:27]=[CH:26][C:20]3[NH:21][C:22](=[O:25])[CH2:23][S:24][C:19]=3[CH:18]=2)[CH:5]=[C:6]([C:8]2([O:14][CH3:15])[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[CH:7]=1.[CH3:28]I>>[F:1][C:2]1[CH:3]=[C:4]([S:16][C:17]2[CH:27]=[CH:26][C:20]3[N:21]([CH3:28])[C:22](=[O:25])[CH2:23][S:24][C:19]=3[CH:18]=2)[CH:5]=[C:6]([C:8]2([O:14][CH3:15])[CH2:9][CH2:10][O:11][CH2:12][CH2:13]2)[CH:7]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 18952061HCID 18952061, compound

Product 1

HCID 18952092HCID 18952092, compoundYield 41%

Procedure

Using the procedure described in Example 12, 4-[5-fluoro-3-(3-oxo-2,3-dihydro-4H-1,4-benzothiazin-7-ylthio)phenyl]-4-methoxytetrahydropyran was reacted with methyl iodide to give 4-[5-fluoro-3-(4-methyl-3-oxo-2,3-dihydro-4H-1,4-benzothiazin-7-ylthio)phenyl]-4-methoxytetrahydropyran in 41% yield, m.p. 131°-133° C.

Sources & evidence

ORD record: ord-d714861ec3bf423cad56e0dad2369581
Source dataset: uspto-grants-1994_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05373007

Reaction notes

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