Fumaric Acid → HCID 178525522, compound

HRID 1492177Notes

Reaction equation

HRID 1492177 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][C:2]1=[N:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[N:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1.[C:20]([OH:27])(=[O:26])/[CH:21]=[CH:22]/[C:23]([OH:25])=[O:24]>CO>[C:20]([OH:27])(=[O:26])/[CH:21]=[CH:22]/[C:23]([OH:25])=[O:24].[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][C:2]1=[N:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[N:14]1[CH2:15][CH2:16][O:17][CH2:18][CH2:19]1

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 178420463HCID 178420463, compound

Product 1

HCID 178525522HCID 178525522, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of the product of Example 1 (10.2 g) in dry methanol (30 ml) was treated with fumaric acid (4.6 g). The resulting solid was filtered and crystallised from methanol to yield 4-[2-(2-piperidinylideneamino)phenyl]morpholine fumerate as a colourless crystalline solid [m.p. 210° C. (dec)].

Workup

  1. filtrationThe resulting solid was filtered
  2. customcrystallised from methanol

Sources & evidence

ORD record
ord-a10872b427eb4191ab13df301f9f34b6
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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